The neighbourhood has its own TSRTC bus terminal, linking it to major suburbs of Hyderabad and Secunderabad, and a Sanathnagar MMTS station for suburban rail. Hyderabad Metro's Red Line is accessible at the adjoining Erragadda station.

A flyover connects Sanathnagar, Fatehnagar and Balkampet, offering a direct route toward Begumpet, and a road-under-bridge linking Sanathnagar to Balanagar through the industrial estate has been planned to ease traffic around the railway yard.

Schools here span several decades, from Covells High School (1964) and St. Theresa's Girls High School (1965) to Hindu Public School, Rose Buds High School, Neena High School, Crescent Convent High School and Vasistha Vidyalaya.

Hindu College for Women is a prominent college in the neighbourhood.

Sanathnagar's industrial estate was set up by the City Improvement Board in 1941 and today houses small and medium chemical, pharmaceutical, electrical and mechanical units alongside larger names such as Gland Pharma, Divi's Laboratories and Bright Star Rubber, plus automobile service centres for Tata Motors, Toyota, Chevrolet, Bajaj, Volvo, Skoda and Mercedes-Benz.

Voltas, Allwyn and Ashok Leyland were formerly based here.

A four-lane, 100-foot road-under-bridge connecting Sanathnagar to Balanagar through the industrial estate has been planned to run beneath the Sanathnagar railway yard, alongside a second flyover planned parallel to the existing Balkampet-Fatehnagar road-over-bridge.

National banks such as State Bank of India and HDFC, and retail anchors like D-Mart, are already established in the neighbourhood.